Topical treatment with a matrix containing mesoglycan in association with hyaluronic acid in the management of chronic skin ulcers of the lower limbs

A chronic skin ulcer in the lower limbs represents the epiphenomenon of pathologies that may involve, at various levels, the venous, arterial, lymphatic and nervous systems of the leg, which must be identified and adequately treated. Recently, there has been increasing evidence that glycosaminoglycans (GAGs) play a role in the re-epithelialization of chronic skin ulcerative wounds of the lower limbs, particularly as regards ulcers of venous and arterial vascular origin. In this paper we report our experience in the treatment of chronic skin ulcers with debridement according to the TIME Wound Bed Preparation protocol with application of a bioactive dressing containing GAGs and hyaluronic acid, compared to a technique using a standard dressing involving the cleansing of the wound with 10% povidone iodine solution.