https://doi.org/10.4081/ijwc.2021.69
Autologous peripheral blood mononuclear cells from selective filtration for treatment of chronic lower limb lesions: Results at 4 years
Submitted: October 13, 2020
Accepted: March 30, 2021
Published: July 30, 2021
Accepted: March 30, 2021
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
A selective filtration technology has recently been introduced on the market to produce an autologous concentrate of Peripheral Blood Mononucleate Cells (PBMNC) with indication for use for human cell therapy. PBMNCs are indicated in the treatment of chronic lower limb injuries. The purpose of this study is to assess the efficacy and tolerability of this treatment in a group of patients who presented skin ulcers of the lower limbs, with various aetiology, not responders to traditional and advanced topical therapies. The study is prospective. Eight patients were treated with a total of 22 skin ulcers with variable etiology. Autologous PBMNCs were implanted along the course of the reference tibial arteries and in the peri-lesional area. All patients were subjected to a cycle of three infiltrations, performed in the operating room, on a monthly basis, except one patient who was subjected to a fourth implant, because the operator considered that a further one would accelerate the already regenerative state of the skin. Of the 22 ulcers treated with this method, 14 have reached complete recovery within a month of the end of the three implants, while 8 have gone towards a clear improvement. All patients showed good compliance to treatment and no minor or major adverse effects were reported. Fifty per cent of the treated patients were followed up four years after the end of treatment, and only one patient had a recurrent skin ulcer, but elsewhere from the initial one. The PBMNCs, produced with selective filtration system, have been shown to be an effective treatment of chronic lesions with different etiology of the lower limbs. The healing of all skin lesions treated quickly, the sharp reduction of pain, and the absence of recurrence at four years suggest a lasting clinical effect over time.
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How to Cite
Bucalossi, M., & Mariani, F. (2021). Autologous peripheral blood mononuclear cells from selective filtration for treatment of chronic lower limb lesions: Results at 4 years. Italian Journal of Wound Care, 5(2). https://doi.org/10.4081/ijwc.2021.69
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