https://doi.org/10.4081/ijwc.2021.79
Hypericum perforatum and Azadirachta indica (Neem) oil in the management of chronic leg ulcers: An uncontrolled retrospective observational case review
Submitted: July 13, 2021
Accepted: September 6, 2021
Published: December 27, 2021
Accepted: September 6, 2021
Abstract Views: 1451
PDF: 121
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Chronic nonhealing leg ulcers are debilitating with high morbidity in a vulnerable patient population and pose a frequent clinical and socioeconomic problem. Numerous local treatment options exist, but clinical trials are rare and wound management still represents a big challenge. Recently a wound dressing based on the natural remedies Hypericum perforatum and Neem oil has been proposed for chronic wound management, but trials on nonhealing leg ulcers are missing. Uncontrolled retrospective observational case review on all patients under our supervision with chronic leg ulcers who underwent treatment with a plant-derived wound dressing based on Hypericum perforatum and Azadirachta indica (Neem) oil. It could be retrieved in a total 16 cases (11 female) with a median age of 71 years. All ulcers (7 ulcers on the leg and 9 ulcers on the feed) showed a complete healing after a median healing time of 82 days (Mean 85, range 14-180 days). No side effects occurred, medication was painless or even reduced pain. Wound dressings based on Hypericum perforatum and Neem oil are well tolerated and could be a potential additional simple treatment option in the management of non-healing leg ulcers. Prospective controlled trials are needed to confirm these observations.
Monari P, Fusano M, Moro R, et al. Correlation between chronic skin ulcers dimension and burden of suffering evaluated with PRISM test. Ital J Dermatol Venerol 2021;156:57-61.
DOI: https://doi.org/10.23736/S2784-8671.19.06423-X
Deluca J, Gatscher B, Tappeiner L, et al. Direct comparison between negative wound pressure therapy and negatively charged polystyrene microspheres in wound bed preparation for split skin grafting in two large symmetric whole circumference leg ulcers, a single patient experience. J Eur Acad Dermatol Venereol 2015;29:1649-51.
DOI: https://doi.org/10.1111/jdv.12527
Là¤uchli S, Hafner J, Wehrmann C, et al. Post-surgical scalp wounds with exposed bone treated with a plant-derived wound therapeutic. J Wound Care 2012;21:228, 230, 232-3.
DOI: https://doi.org/10.12968/jowc.2012.21.5.228
Mainetti S, Carnevali F. An experience with paediatric burn wounds treated with a plant-derived wound therapeutic. J Wound Care 2013;22:681-2, 684-5, 688-9.
DOI: https://doi.org/10.12968/jowc.2013.22.12.681
Franco P, Rampino M, Ostellino O, et al. Management of acute skin toxicity with Hypericum perforatum and neem oil during platinum-based concurrent chemo-radiation in head and neck cancer patients. Med Oncol 2017;34:30.
DOI: https://doi.org/10.1007/s12032-017-0886-5
Franco P, Potenza I, Moretto F, et al. Hypericum perforatum and neem oil for the management of acute skin toxicity in head and neck cancer patients undergoing radiation or chemo-radiation: a single-arm prospective observational study. Radiat Oncol 2014;29:297.
DOI: https://doi.org/10.1186/s13014-014-0297-0
Iabichella ML. The use of an extract of Hypericum perforatum and Azadirachta indica in advanced diabetic foot: an unexpected outcome. BMJ Case Rep 2013;2013:bcr2012007299.
DOI: https://doi.org/10.1136/bcr-2012-007299
Iabichella ML, Caruso C, Lugli M. The use of an extract of Hypericum perforatum and Azadirachta indica in a neuropathic patient with advanced diabetic foot. BMJ Case Rep 2014;2014:bcr2014205706.
DOI: https://doi.org/10.1136/bcr-2014-205706
Là¤uchli S, Vannotti S, Hafner J, et al. A plant-derived wound therapeutic for cost-effective treatment of post-surgical scalp wounds with exposed bone. Forsch Komplementmed 2014;21:88-93.
DOI: https://doi.org/10.1159/000360782
Wà¶lfle U, Seelinger G, Schempp CM. Topical application of St. John's wort (Hypericum perforatum). Planta Med 2014;80:109-20.
DOI: https://doi.org/10.1055/s-0033-1351019
Alzohairy MA. Therapeutics role of Azadirachta indica (Neem) and their active constituents in diseases prevention and treatment. Evid Based Complement Alternat Med 2016;2016:7382506.
DOI: https://doi.org/10.1155/2016/7382506
Bridi H, Beckenkamp A, Maurmann N, et al. Phloroglucinol derivatives from Hypericum species induce in vitro proliferation of cells involved in the wound healing process. Nat Prod Res 2019;1â€5.
DOI: https://doi.org/10.1080/14786419.2019.1698576
Seyhan N. Evaluation of the healing effects of Hypericum perforatum and Curcumin on burn wounds in rats. Evid Based Complement Alternat Med 2020;2020:6462956.
DOI: https://doi.org/10.1155/2020/6462956
Gautam MK, Gangwar M, Singh SK, Goel RK. Effects of Azardirachta indica on vascular endothelial growth factor and cytokines in diabetic deep wound. Planta Med 2015;81:713-21.
DOI: https://doi.org/10.1055/s-0035-1545917
Yà¼cel A, Kan Y, Yesilada E, Akın O. Effect of St.John's wort (Hypericum perforatum) oily extract for the care and treatment of pressure sores; a case report. J Ethnopharmacol 2017;196:236-241.
DOI: https://doi.org/10.1016/j.jep.2016.12.030
Giuggioli D, Lumetti F, Spinella A, et al. Use of Neem oil and Hypericum perforatum for treatment of calcinosis-related skin ulcers in systemic sclerosis. J Int Med Res 2020;48:300060519882176.
DOI: https://doi.org/10.1177/0300060519882176
Whitehead AJ, Nelson NW, Brame LS, Champlin FR. Endemic North American plants as potentially suitable agents for wound cleaning under resource scarce conditions. Wilderness Environ Med 2019;30:401-6.
DOI: https://doi.org/10.1016/j.wem.2019.06.002
Singh A, Singh AK, Narayan G, et al. Effect of Neem oil and Haridra on non-healing wounds. Ayu 2014;35:398-403.
DOI: https://doi.org/10.4103/0974-8520.158998
How to Cite
Turk, L., Thuile, T., De Marzi, V., Antonacci, G., Puviani, M., & Eisendle, K. (2021). <em>Hypericum perforatum</em> and <em>Azadirachta indica</em> (Neem) oil in the management of chronic leg ulcers: An uncontrolled retrospective observational case review. Italian Journal of Wound Care, 5(2). https://doi.org/10.4081/ijwc.2021.79
Copyright (c) 2021 The Authors
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Federica Buzzi, Hevan Adel Al-Atroushy, Nizar Bakir Yahya, Hozan Dilneya Rwanduzi, Stefano Maindi, Is it possible to use a 100% Medical Grade Honey in the premature babies? , Italian Journal of Wound Care: Vol. 5 No. 2 (2021)
- Katia Feliziani, Arianna Dichiara, Giovanna Faccenda, Marco Romanelli, Battistino Paggi, Empowerment and patient-centered care: A therapeutic educational project for patient with venous ulcers. A pilot study , Italian Journal of Wound Care: Vol. 5 No. 1 (2021)
- Alberto Garavello, Margherita Lo Ponte, Stefania Gilardi, Paola Fiamma, Massimo Tozzi, Recurrent venous leg ulcers: clinical analysis of an experience , Italian Journal of Wound Care: Vol. 3 No. 2 (2019)
- Giuseppe Nebbioso, Viviana Nebbioso, Carmela Orefice, Francesco Petrella, Ciro Falasconi, Health literacy, empowerment and communication in wound care management , Italian Journal of Wound Care: Vol. 2 No. 2 (2018)
- Carla Pezzuto, Nadia Felisi, Nadia Crispini, Ilaria Rosso, Use of photobiomodulation with blue light in the treatment of ulcers of various etiology in spinal cord injured patients: a case series , Italian Journal of Wound Care: Vol. 7 No. 2 (2023)
- Michela Crisci, Giovanni Lepore, Federica Feleppa, Alessandro Crisci, Fabiana Flagiello, Cytomorphological analysis of liquid platelet-rich fibrin produced with the DUO fixed angle centrifuge (Process, France) for use in the regenerative therapy of skin ulcers , Italian Journal of Wound Care: Vol. 7 No. 3 (2023)
- Marina Pierangeli, Giovanni Ruocco, Vanya Recchi, Valentina Cecconato, Costanza Binci, Yasmine Zavalloni, Davide Talevi, Matteo Torresetti, Giovanni Di Benedetto, Alessandro Scalise, Medical Honey in clinical practice: our experience in 75 treated cases , Italian Journal of Wound Care: Vol. 4 No. 1 (2020)
- Margherita Farì, Maurizio Mercuri , Alessandro Scalise , Continuity of care in the management of pressure lesions: An information leaflet for hospital-territory collaboration , Italian Journal of Wound Care: Vol. 5 No. 1 (2021)
- Fiorella Riservati, Negative pressure therapy: costs and benefits , Italian Journal of Wound Care: Vol. 2 No. 3 (2018)
- Giuseppe Nebbioso, Ciro Falasconi, Viviana Nebbioso, Francesco Petrella, Pain and chronic skin ulcers , Italian Journal of Wound Care: Vol. 4 No. 1 (2020)
You may also start an advanced similarity search for this article.