https://doi.org/10.4081/ijwc.2022.89
Observational study of a gauze medication contaning Rigenase® and polyhexanide in the treatiment of venous leg ulcers (<6cm2) and perilesional skin
Submitted: May 16, 2022
Accepted: June 27, 2022
Published: July 29, 2022
Accepted: June 27, 2022
Abstract Views: 510
PDF: 125
PDF (Italiano): 320
Appendix (Italiano): 40
PDF (Italiano): 320
Appendix (Italiano): 40
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
The Triticum Vulgare Extract (TVE) is a particular wheat extract patented by Farmaceutici Damor. TVE (Rigenase®) has been shown to have an important bio stimulation effect promoting the tissue repairing process in vitro. In this context, an observational study was developed to access the effects of a gauze based on Rigenase® and polyhexanide in the treatment of venous ulcers (area <6 cm2 and not beyond the dermal layer) and of damaged perilesional skin whose damage could have also been determined by iatrogenic cause. Inclusion and exclusion criteria were identified and a medication protocol was applied. The study showed that the product based on Rigenase® and polyhexanide is effective in the treatment of venous ulcers and damaged perilesional skin.
Funel N, Dini V, Janowska A, et al. Triticum vulgare extract modulates protein-kinase B and matrix metalloproteinases 9 protein expression in BV-2 cells: Bioactivity on inflammatory pathway associated with molecular mechanism wound healing. Mediators Inflamm 2020;2020:2851949.
DOI: https://doi.org/10.1155/2020/2851949
Sanguigno L, Casamassa A, Funel N, et al. Triticum vulgare extract exerts an anti-inflammatory action in two in vitro models of inflammation in microglial cells. PLoS One 2018;13:e0197493.
DOI: https://doi.org/10.1371/journal.pone.0197493
Tito A, Minale M, Riccio S, et al. A Triticum vulgare extract exhibits regenerating activity during the wound healing process. Clin Cosmet Investig Dermatol 2020;13:21-30.
DOI: https://doi.org/10.2147/CCID.S216391
D’Agostino A, Pirozzi AVA, Finamore R, et al. Molecular mechanisms at the basis of pharmaceutical grade Triticum vulgare extract efficacy in prompting keratinocytes healing. Molecules 2020;25:431.
DOI: https://doi.org/10.3390/molecules25030431
Antonucci I, Fiorentino G, Contursi P, et al. Antioxidant capacity of Rigenase®, a specific aqueous extract of Triticum vulgare. Antioxidants (Basel) 2018;7:67.
DOI: https://doi.org/10.3390/antiox7050067
Atkin L, Bućko Z, Conde Montero E, et al. Implementing TIMERS: The race against hard-to-heal wounds. J Wound Care 2019;23:S1-S50.
DOI: https://doi.org/10.12968/jowc.2019.28.Sup3a.S1
Stillo F, Ebner H, Lanza G, et al. Linee Guida SICVE/SIF 2016. Ital J Vasc Endovasc Surg 2016;3:1-45.
How to Cite
Petrella, F., Nebbioso, G., Aquino, M., Bellisi, M., Carella, S., Catalfamo, R. G., … Scanguzzi, A. (2022). Observational study of a gauze medication contaning Rigenase® and polyhexanide in the treatiment of venous leg ulcers (<6cm2) and perilesional skin. Italian Journal of Wound Care, 6(2). https://doi.org/10.4081/ijwc.2022.89
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