https://doi.org/10.4081/ijwc.2023.95
Use of biological products in the healing process of skin lesions
Submitted: January 30, 2023
Accepted: March 9, 2023
Published: April 6, 2023
Accepted: March 9, 2023
Abstract Views: 569
PDF (Italiano): 350
PDF: 51
PDF: 51
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Research in the chemical and techno-pharmacological sector has allowed the use of medical devices based on biological products in the various phases of the tissue repair process of acute and chronic wounds. Neem and St. John’s Wort oil, Aloe vera, essential fatty acids are applied to the wound only after non-vital tissue has been removed and in the absence of biofilm and/or infection. Honey, on the other hand, is used in the debridement phase thanks to its biological-natural properties and the ability to draw water from the tissues surrounding the lesion, thus allowing the detachment of the non-vital tissue from the wound bed (autolytic debridement). In the presence of biofilm or wound infection, the only indicated debridement is surgical. The study evaluated the possibility of using the autolytic properties of honey on lesions even in the presence of biofilm or local infection, demonstrating how such use is possible especially in patients in whom surgical debridement is contraindicated.
Falanga V. Classifications for wound bed preparation and stimulation of chronic wounds. Wound Repair Regen 2000;8:347-52
DOI: https://doi.org/10.1111/j.1524-475X.2000.00347.x
Baharestani M. The clinical relevance of debridement. In: Baharestani M, Goltrup F, Holstein P, Vanscheidt W (eds). The clinical relevance of debridement. Springer-Verlag, Berlin, Heidelberg; 1999.
Baharestani M, Goltrup F, Holstein P, Vanscheidt W (eds). The clinical relevance of debridement. Springer-Verlag, Berlin, Heidelberg; 1999.
Schultz GS, Sibbald RG, Falanga V, et al. Wound bed preparation: a systematic approach to wound management. Wound Repair Regen 2003;11:S1-28.
DOI: https://doi.org/10.1046/j.1524-475X.11.s2.1.x
Sibbald RG, Elliott JA, Persaud-Jaimangal R, et al. Wound Bed Preparation 2021. Adv Skin Wound Care 2021;34:183-95.
DOI: https://doi.org/10.1097/01.ASW.0000733724.87630.d6
Strohal R, Dissemond J, Jordan O'Brien J, et al. EWMA Document: debridement. J Wound Care 2013;22:S1–5.
DOI: https://doi.org/10.12968/jowc.2013.22.Sup5.S1
Beitz JM. Wound debridement: treatment options and care considerations. Nurs Clin North Am 2005;40:233-49.
DOI: https://doi.org/10.1016/j.cnur.2004.09.004
Chaiken N. Pressure ulceration and the use of Active Leptospermum honey for debridement and healing. Ostomy Wound Management 2010;56:12-14.
Abuda Z, Zerdan I, Kalalo I, et al. The antibacterial activity of Moroccan bee bread and bee pollen (fresh and dried) against pathogenic bacteria. Ris J Microbiolo 2011;6:376–38
DOI: https://doi.org/10.3923/jm.2011.376.384
Pita-Calvo C, Vázquez M. Differences between honeydew and blossom honeys: A review Trends Food Sci Technol 2017;59:79-87.
DOI: https://doi.org/10.1016/j.tifs.2016.11.015
Gethin G. Understanding the significance of surface pH in chronic wounds. WOUNDS UK 2007;3. Available from: https://www.wounds-uk.com/journals/issue/11/article-details/the-significance-of-surface-ph-in-chronic-wounds-1
Kędzia B, Hołderna-Kędzia E. Opinioni contemporanee sul meccanismo dell'azione antimicrobica del miele. Postep Fitoter 2017;4:290-7.
Bang LM, Buntting C, Molan PC. The effect of dilution on the rate of hydrogen peroxide production in honey and its implications for wound healing. J Altern Complement Med 2003;9:267–73.
DOI: https://doi.org/10.1089/10755530360623383
Mavric E, Wittmann S, Barth G, Henle T. Identification and quantification of methylglyoxal as the dominant antibacterial constituent of manuka (Leptospermum scoparium) honeys from New Zealand. Mol Nutr Foods Res 2008;52:483–9.
DOI: https://doi.org/10.1002/mnfr.200700282
Minden-Birkenmaier BA, Bowlin GL. Modelli a base di miele nella guarigione delle ferite e nell'ingegneria tissutale. Bioingegneria 2018;5:46
DOI: https://doi.org/10.3390/bioengineering5020046
Visavadia BG, Honeysett J, Danford MH. Medicazione al miele di Manuka: un trattamento efficace per le infezioni croniche delle ferite. Br J Maxillofac Surg 2006;44:38–41.
Karayil S, Deshpande SD, Koppikar GV. Effect of honey on multidrug resistant organisms and its synergistic action with three common antibiotics. J Postgrad Med 1998;44:93–6.
Merckoll P, Jonassen TØ, Vad ME, et al. Bacteria, biofilm and honey: a study of the effects of honey on 'planktonic' and biofilm-embedded chronic wound bacteria. Scand J Infect Dis 2009;41:341-7.
DOI: https://doi.org/10.1080/00365540902849383
Maddocks S, Lopez M, Rowlands R, Cooper R. Manuka honey inhibits the development of Streptococcus pyogenes biofilms and causes reduced expression of two fibronectin binding proteins. Microbiology (Reading, England) 2012;158:781-90.
DOI: https://doi.org/10.1099/mic.0.053959-0
Kędzia B, Hołderna-Kędzia, E. Allergenne oddziannlywanie miodu na organizm czlowieka. [Allergenic effects of honey on human organism.] Pasieka 2011, 6
Tomblin V, Ferguson LR, Han DY, et al. Potential pathway of anti-inflammatory effect by New Zealand honeys. Int J Gen Med 2014;7:149–58.
DOI: https://doi.org/10.2147/IJGM.S45839
How to Cite
Nebbioso, V., Nebbioso, G., Petrella, F., & Naviglio, D. (2023). Use of biological products in the healing process of skin lesions. Italian Journal of Wound Care, 7(1). https://doi.org/10.4081/ijwc.2023.95
Copyright (c) 2023 the Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Giuseppe Nebbioso, Ciro Falasconi, Viviana Nebbioso, Francesco Petrella, Antiseptics and control of bacterial load in venous ulcers , Italian Journal of Wound Care: Vol. 2 No. 2 (2018)
- Riccardo Garcea, Paolo Savelli, Kennedy’s terminal ulcer and pressure injury: two different aspects of medical liability related to the same injury , Italian Journal of Wound Care: Vol. 7 No. 2 (2023)
- Alessandro Crisci, Carmela Rescigno, Michela Crisci, The L-PRF membrane and its derivatives useful in wound care surgery , Italian Journal of Wound Care: Vol. 3 No. 1 (2019)
- Carla Pezzuto, Nadia Felisi, Nadia Crispini, Ilaria Rosso, Use of photobiomodulation with blue light in the treatment of ulcers of various etiology in spinal cord injured patients: a case series , Italian Journal of Wound Care: Vol. 7 No. 2 (2023)
- Margherita Farì, Maurizio Mercuri , Alessandro Scalise , Continuity of care in the management of pressure lesions: An information leaflet for hospital-territory collaboration , Italian Journal of Wound Care: Vol. 5 No. 1 (2021)
- Michela Crisci, Giovanni Lepore, Federica Feleppa, Alessandro Crisci, Fabiana Flagiello, Cytomorphological analysis of liquid platelet-rich fibrin produced with the DUO fixed angle centrifuge (Process, France) for use in the regenerative therapy of skin ulcers , Italian Journal of Wound Care: Vol. 7 No. 3 (2023)
- Paola Leonardelli, Rachele Stelzer, Patient with skin injuries in home care: Advice from the expert wound care nurse. Define and standardize the process at a territorial level , Italian Journal of Wound Care: Vol. 6 No. 2 (2022)
- Giuseppe Nebbioso, Ciro Falasconi, Viviana Nebbioso, Francesco Petrella, Pain and chronic skin ulcers , Italian Journal of Wound Care: Vol. 4 No. 1 (2020)
- Deborah Cesura Granara , Anna Baxa, Cinzia Viaggi, Cristina Pruzzo, Giorgia Piana, Giorgio Badino, Miriam Roccaforte, Silvia Pienovi, Tiziana Zuliani, Marco Marchelli, Giuseppe Perniciaro, Carmelo Gagliano, Luigi Carlo Bottaro, Impact of the wound hygiene concept on wound contraction: an experience by ‘Vulnologia ASL3 Regione Liguria’ , Italian Journal of Wound Care: Vol. 7 No. 3 (2023)
- Francesco Petrella, Giuseppe Nebbioso, Marcello Aquino, Mario Bellisi, Sara Carella, Rosaria Grace Catalfamo, Diletta Donateo, Pasquale Esposito, Pierluigi Gallo, Maria Grazia Mezzasalma, Stefano Riccardi, Concetta Romano, Alessandro Scanguzzi, Observational study of a gauze medication contaning Rigenase® and polyhexanide in the treatiment of venous leg ulcers (<6cm2) and perilesional skin , Italian Journal of Wound Care: Vol. 6 No. 2 (2022)
You may also start an advanced similarity search for this article.
