https://doi.org/10.4081/ijwc.2023.96
Topical application of cannabinoid-based galenic preparations for pain treatment in chronic leg ulcer: case reports
Submitted: February 11, 2023
Accepted: March 7, 2023
Published: April 6, 2023
Accepted: March 7, 2023
Abstract Views: 407
PDF (Italiano): 210
PDF: 59
PDF: 59
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Chronic leg ulcers are disabling and often painful. Venous leg ulcers (VLU) affect mainly the elderly and represent a condition of discomfort and poor quality of life. Pain at dressing changes, for these patients, is a particularly feared and stressful procedure leading to anxiety. Topical cannabinoid treatment is an innovative treatment choice for pain modulation and reduction when treating VLU. A Canadian study showed promising results when using topical application of cannabis in patients with pyoderma gangrenous. We therefore proposed to conduct a study on cannabinoids in the management of VLU with two types of galenic preparations. Three patients were treated, with Cannabis Oil Flos (Bedrocan®) (19-22% THC; CBD<1%). The Cannabis Oil Flos showed good effectiveness in reducing painful symptoms and reducing the need for oral analgesics.
Maida V, Corban J. Topical Medical Cannabis (TMC): A new treatment for wound pain. Three cases of pyoderma gangrenosum. J Pain Symptom Manag 2017;54:732-6.
DOI: https://doi.org/10.1016/j.jpainsymman.2017.06.005
Hellström A, Nilsson C, Nilsson A, Fagerström C. Leg ulcers in older people: a national study addressing variation in diagnosis, pain and sleep disturbance. BMC Geriatrics 2016;16:25.
DOI: https://doi.org/10.1186/s12877-016-0198-1
Kelechi TJ, Johnson JJ; WOCN Society. Guideline for the management of wounds in patients with lower-extremity venous disease: an executive summary. J Wound Ostomy Continence Nurs 2012;39:598-606.
DOI: https://doi.org/10.1097/WON.0b013e31827179e9
Pannier F, Rabe E. Differential diagnosis of leg ulcers. Phlebology 2013;28:55-60.
DOI: https://doi.org/10.1177/0268355513477066
Zech DF, Grond S, Lynch J, Hertel D, Lehmann KA. Validation of World Health Organization Guidelines for cancer pain relief: a 10-year prospective study. Pain 1995;63:65-76.
DOI: https://doi.org/10.1016/0304-3959(95)00017-M
Ryan- Ibarra S, Induni M, Ewing D. Prevalence of medical marijuana use in California, 2012. Drug Alcohol Rev 2015;34;141-6.
DOI: https://doi.org/10.1111/dar.12207
Adler JN, Colbert JA. Clinical decisions. Medicinal use of marijuana polling results. N Engl J Med 2013;368:e30.
DOI: https://doi.org/10.1056/NEJMclde1305159
Gaoni Y, Mechoulam R. Isolation, structure, and partial synthesis of an active constituent of Hashish. J Am Chem Soc 1964:86:1646–7.
DOI: https://doi.org/10.1021/ja01062a046
How to Cite
Polignano, R., Gatto, R., Ruffino, I., Pavanelli, A., & Falciani, F. (2023). Topical application of cannabinoid-based galenic preparations for pain treatment in chronic leg ulcer: case reports. Italian Journal of Wound Care, 7(1). https://doi.org/10.4081/ijwc.2023.96
Copyright (c) 2023 the Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Francesco Petrella, Franca Abbritti, Francesca Bachetti, Sonia Brizzi, Michele Bruscella, Piero Baà¹, Mario Cala, Ferdinando Campitiello, Giovanna Capace, Massimo Calveri, Marina Comandini, Giovanni Vito Corona, Teresa Cosentino, Amarilli Croce Casalena, Cinzia Datteri, Cristiana Di Campli, Raffaele Di Nardo, Enrica Di Spirito, Filomena Discenza Spensieri, Ciro Falasconi, Michele Angelo Farina, Caterina Favaro, Domitilla Foghetti, Andrea Frasca, Manuela Galleazzi, Pierluigi Gallo, Luca Gazzabin, Ivo Gerbelle, Manuela Germano, Francesco Giacinto, Serena Giannini, Giorgio Guarnera, Klarida Hoxha, Vincenzo Labbro, Vincenzo Lauletta, Deianira Luciani, Giuseppe Maierà , Giuseppe Maccarone, Cosimo Maglio, Paolo Mascioli, Vincenzo Mattaliano, Massimo Menculini, Piermauro Miraglia, Giovanni Battista Mosti, Marcello Napolitano, Giuseppe Nebbioso, Pamela Orazi, Fabio Pacifico, Maurizio Palombi, Piergiorgio Pastore, Marina Pierangeli, Stefano Priolo, Marco Romanelli, Donatella Rossolini, Elisa Ronzullo, Maria Teresa Scalise, Patrizia Scarpelli, Piero Secreto, Claudio Solinas, Marilena Tender, Stefano Trovò, I.S.U.S. PROJECT (ITALIAN SKIN ULCER STUDY) (1 January 2015-31 December 2016). Final data , Italian Journal of Wound Care: Vol. 1 No. 1 (2017)
- Giuseppe Nebbioso, C. Albanese, F. Bonat, A. Botta, Giovanni Vito Corona, Cira Costagliola, Corrado Maria Durante, Ciro Falasconi, D. Foglietti, Francesco Giacinto, Pasquale Longobardi, Klarida Hoxha, Cosimo Maglio, Vincenzo Mattaliano, Massimo Menculini, Giovanni Battista Mosti, Carmela Orefice, Sonia Remafedi, Donatella Rossolini, Felice Tafuro, Francesco Petrella, Quality of life study in Wound Care. Final report , Italian Journal of Wound Care: Vol. 1 No. 1 (2017)
- Fabio Mozzarelli, Sara Gaetti, Assessment of vascular ulcers of the lower limbs through the Wound Trend Scale: the experience of the Local Health Authority of Piacenza , Italian Journal of Wound Care: Vol. 2 No. 1 (2018)
- Ciro Falasconi, Vincenzo Amalfi, Patrizia Baroni, Giovanni Vito Corona, Corrado Maria Durante, Paola Fanin, Caterina Favaro, Massimo Fornaciari, Alessandro Farris, Manuela Galleazzi, Francesco Giacinto, Giorgio Guarnera, Vincenzo Lauletta, Mario Marazzi, Marco Masina, Vincenzo Mattaliano, Giovanni Battista Mosti, Giuseppe Nebbioso, Francesco Stanganello, Francesco Petrella, Survey on issues concerning eHealth and telemedicine in Wound Care , Italian Journal of Wound Care: Vol. 1 No. 1 (2017)
- Ciro Falasconi, Vincenzo Amalfi, Patrizia Baroni, Giovanni Vito Corona, Corrado Maria Durante, Paola Fanin, Caterina Favaro, Massimo Fornaciari, Alessandro Farris, Manuela Galleazzi, Francesco Giacinto, Giorgio Guarnera, Vincenzo Lauletta, Mario Marazzi, Marco Masina, Vincenzo Mattaliano, Giovanni Battista Mosti, Giuseppe Nebbioso, Francesco Stanganello, Francesco Petrella, Survey on pain in patients with chronic skin lesions , Italian Journal of Wound Care: Vol. 1 No. 1 (2017)
- Francesco Giacinto, Ciro Falasconi, Elisabetta Giacinto, Manuela Germano, Domenica Ciuffoletti, The use of modern technologies based on telemedicine in wound care: experience in high-tyrrhenian region and the province of Cosenza, Italy , Italian Journal of Wound Care: Vol. 2 No. 1 (2018)
- Matteo Torresetti, Giovanni Di Benedetto, Alessandro Scalise, Is there an alternative to acellular dermal matrix for wound management? Revisiting the role of a bioactive collagen and hyaluronic acid-based dressing hyaluronic acid , Italian Journal of Wound Care: Vol. 4 No. 2 (2020)
- Romina Corgiat-Loia, Lucia Pavignano, Marcella Vargiu, Laura Perono Minino, Giovanna Capace, Fabrizia Cogo, Lucia Carlino, Chiara Mangolini, Marzia Soave, Eraldo Personettaz, Enrica Bertotti, Fabrizio Aprà , Carla Varola, Cristina Amato, Eleonora Aloi, Looking beyond...a path started in ASL TO4 for the treatment of chronic skin lesions , Italian Journal of Wound Care: Vol. 2 No. 2 (2018)
- Paola Pini, The skin microbiota and its interactions with the host , Italian Journal of Wound Care: Vol. 6 No. 1 (2022)
- Chiara Bissoni, Klarida Hoxha, Alessandro Scalise, Pasquale Longobardi, Hyperbaric oxygen therapy and negative pressure wound therapy in the treatment of non-healing wounds , Italian Journal of Wound Care: Vol. 2 No. 3 (2018)
You may also start an advanced similarity search for this article.
